Figure 8

Imaging modalities delivery of RNAi therapeutics in cancer therapy and clinical applications

Loutfy H Madkour*

Published: 04 March, 2021 | Volume 5 - Issue 1 | Pages: 005-034

in vivo antitumor efficacy of PTX/HAI-NGs inMCF-7 tumor bearing nude mice. Free PTX and PBS were used as controls. The drug was given on day 0, 3, 6, 9, 12 (drug dosage: 5mg PTX equiv/kg). (A) Tumor volume changes in time. Data are presented as mean ± SD (n = 6). (B) Photographs of tumor blocks collected from different treatment groups on day 24. (C) Body weight changes of nude mice following different treatments within 24 days. (D) Survival rates of mice in different treatment groups within 60 d. Data are presented as means ± SD (n = 5). *p < 0.05, *** p < 0.001. (E) H&E stained heart, liver, kidney and tumor sections excised from MCF-7 human breast tumor-bearing mice following 24 d treatment with PTX/HAINGs, free PTX or PBS. The images were obtained by a Leica microscope at 200× magnification. Red arrows indicate hepatocellular necrosis.

" alt="jro-aid1035-g018"class="img-responsive img-rounded " style="cursor:pointer">

Figure 8:

in vivo antitumor efficacy of PTX/HAI-NGs inMCF-7 tumor bearing nude mice. Free PTX and PBS were used as controls. The drug was given on day 0, 3, 6, 9, 12 (drug dosage: 5mg PTX equiv/kg). (A) Tumor volume changes in time. Data are presented as mean ± SD (n = 6). (B) Photographs of tumor blocks collected from different treatment groups on day 24. (C) Body weight changes of nude mice following different treatments within 24 days. (D) Survival rates of mice in different treatment groups within 60 d. Data are presented as means ± SD (n = 5). *p < 0.05, *** p < 0.001. (E) H&E stained heart, liver, kidney and tumor sections excised from MCF-7 human breast tumor-bearing mice following 24 d treatment with PTX/HAINGs, free PTX or PBS. The images were obtained by a Leica microscope at 200× magnification. Red arrows indicate hepatocellular necrosis.

Read Full Article HTML DOI: 10.29328/journal.jro.1001035 Cite this Article Read Full Article PDF

More Images

Similar Articles

Recently Viewed

Read More

Most Viewed

Read More

Help ?