Abstract

Opinion

From Ashes to Life - The Indestructible D. radiodurans

João DT Arruda-Neto*, Henriette Righi and Amanda M Lacerda

Published: 15 July, 2024 | Volume 8 - Issue 2 | Pages: 072-073

Deinococcus radiodurans (D. radiodurans) was accidentally discovered in 1956 when cans of ground meat were exposed to massive doses of ionizing gamma radiation, intended to kill dangerous bacteria. The bacterium can survive doses of radiation, even up to 1,000 times that which is deadly to humans. Among biologists and biophysicists, D. radiodurans is often humorously called “Conan the Bacterium.” This extreme radioresistance of the bacterium has been attributed to its ability to protect the proteome from ROS, which originates from water radiolysis, and also to carry out the effective repair of a large amount of DNA damage.

Read Full Article HTML DOI: 10.29328/journal.jro.1001067 Cite this Article Read Full Article PDF

Keywords:

Radiation-resistant; DNA damage; DNA repair

References

  1. Anderson A, Nordon Hc, Cain RF, Parrish G, Duggan D, Anderson A. Studies on a radio-resistant micrococcus. I. Isolation, morphology, cultural characteristics, and resistance to gamma radiation. Food Technol. 1956;10(1):575-577. Available from: https://www.semanticscholar.org/paper/Studies-on-a-radio-resistant-micrococcus.-I.-and-to-Anderson-Nordon/10108eeb961a2a3b7f1a9e2fd139b714da6a58e7
  2. Huyghe P. Conan the bacterium. The Sciences. 1998; 38(4):16. Available from: https://openurl.ebsco.com/EPDB%3Agcd%3A13%3A6063805/detailv2?sid=ebsco%3Aplink%3Ascholar&id=ebsco%3Agcd%3A813317&crl=c
  3. Krisko A, Radman M. Protein damage and death by radiation in Escherichia coli and Deinococcus radiodurans. Proc Natl Acad Sci U S A. 2010;107(32):14373-7. Available from: https://pubmed.ncbi.nlm.nih.gov/20660760/
  4. Krisko A, Radman M. Biology of extreme radiation resistance: the way of Deinococcus radiodurans. Cold Spring Harb Perspect Biol. 2013;5(7):a012765. Available from: https://pubmed.ncbi.nlm.nih.gov/23818498/
  5. Daly MJ. A new perspective on radiation resistance based on Deinococcus radiodurans. Nat Rev Microbiol. 2009;7(3):237-245. Available from: https://pubmed.ncbi.nlm.nih.gov/19172147/
  6. Daly MJ, Gaidamakova EK, Matrosova VY, Kiang JG, Fukumoto R, Lee DY, et al. Small-molecule antioxidant proteome-shields in Deinococcus radiodurans. PLoS One. 2010 Sep 3;5(9):e12570. Available from: https://pubmed.ncbi.nlm.nih.gov/20838443/
  7. Arruda-Neto JD, Righi H, Gomez JG, da Silva LF, Drigo E, da Costa Lemos AC. Radioresistance and radiosensitivity: a biophysical approach on bacterial cells robustness. Theory Biosci. 2022;142:13-28. Available from: https://link.springer.com/article/10.1007/s12064-022-00382-w
  8. Guinness World Records. "Most radiation-resistant lifeform". 2015. Available from: https://www.guinnessworldrecords.com/world-records/most-radiation-resistant-lifeform

Figures:

Similar Articles

  • From Ashes to Life - The Indestructible D. radiodurans
    João DT Arruda-Neto*, Henriette Righi and Amanda M Lacerda João DT Arruda-Neto*, Henriette Righi, Amanda M Lacerda. From Ashes to Life - The Indestructible D. radiodurans. . 2024 doi: 10.29328/journal.jro.1001067; 8: 072-073

Recently Viewed

Read More

Most Viewed

Read More

Help ?